The crash occurred on the eastbound side of the highway near Sophie Street in Readington Township, local police said just before 3:30 p.m.
One person was killed and another was being airlifted in cardiac arrest following the crash, according to initial and unconfirmed reports.
A Northstar medical helicopter was landing at the crash scene, the initial report says.
This is a developing story. Check back for more.
Click here to follow Daily Voice Wyckoff-Franklin Lakes and receive free news updates.